Risk factors for primary liver cancer include Having hepatitis, having cirrhosis, or scarring of the liver, being male, Low weight at birth. Persons with associated cirrhosis brought on by chronic hepatitis B or C infections, alcohol, and hemochromatosis have the highest risk of developing this kind of cancer.

 Liver cancer is the third leading cause of cancer deaths in the world after lung and stomach cancer

The cause of liver cancer is usually cirrhosis (scarring of the liver). Cirrhosis may be caused by viral hepatitis, primarily hepatitis B and C, alcohol abuse, hemochromatosis, certain auto-immune diseases of the liver, and other diseases that result in chronic inflammation of the liver.